CAGRISEMA (Cagrilintide 5mg + Semaglutide 5mg)
$83.77
- Semaglutide activates GLP-1 receptors. It slows gastric emptying, enhances glucose-dependent insulin secretion, suppresses glucagon, and acts on appetite centers in the hypothalamus and brainstem to reduce hunger and food intake.
- Cagrilintide activates amylin and calcitonin receptors. Amylin is co-secreted with insulin from pancreatic beta cells and signals meal-related fullness through the area postrema in the brainstem — anatomically and pharmacologically distinct from GLP-1 signaling.